Influence of vehicles used for oral dosing of test molecules on the progression of Mycobacterium tuberculosis infection in mice.
Antimicrob Agents Chemother
; 56(11): 6026-8, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22926571
ABSTRACT
Preclinical evaluation of drug-like molecules requires their oral administration to experimental animals using suitable vehicles. We studied the effect of oral dosing with corn oil, carboxymethyl cellulose, dimethyl sulfoxide, and polysorbate-80 on the progression of Mycobacterium tuberculosis infection in mice. Infection was monitored by physical (survival time and body weight) and bacteriological (viable counts in lungs) parameters. Compared with water, corn oil significantly improved both sets of parameters, whereas the other vehicles affected only physical parameters.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polissorbatos
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Tuberculose Pulmonar
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Óleo de Milho
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Portadores de Fármacos
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Carboximetilcelulose Sódica
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Água
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Dimetil Sulfóxido
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Mycobacterium tuberculosis
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article