Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases.
Org Lett
; 14(17): 4303-5, 2012 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-22928597
ABSTRACT
The total synthesis of (+)-Sch 725680, a member of the hydrogenated azaphilone family, has been accomplished. The synthesis confirmed the absolute configuration and biological activities of the natural product. A key reaction to construct a hydrogenated azaphilone core skeleton is a Ti-mediated aldol reaction.
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Base de dados:
MEDLINE
Assunto principal:
Benzopiranos
/
Inibidores da Síntese de Ácido Nucleico
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article