Diversity oriented synthesis of pyran based polyfunctional stereogenic macrocyles and their conformational studies.

Ajay, Arya; Sharma, Shrikant; Gupt, Munna Prasad; Bajpai, Vikas; Kumar, Brijesh; Kaushik, Mahabir Prasad; Konwar, Rituraj; Ampapathi, Ravi Sankar; Tripathi, Rama Pati

Ajay, Arya; Sharma, Shrikant; Gupt, Munna Prasad; Bajpai, Vikas; Kumar, Brijesh; Kaushik, Mahabir Prasad; Konwar, Rituraj; Ampapathi, Ravi Sankar; Tripathi, Rama Pati.

Afiliação

Ajay A; Medicinal and Process Chemistry Division, Sophisticated Analytical Instrumentation Facility, Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow-226001, U.P., India.

Org Lett ; 14(17): 4306-9, 2012 Sep 07.

Article em En | MEDLINE | ID: mdl-22931313

RESUMO

A new approach to synthesize a homologous series of 14-, 15-, and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in designed C-glycopyranosyl butenones from a simple sugar d-glucose and d-mannose is reported.

Assuntos

Glicoconjugados/síntese química; Compostos Macrocíclicos/síntese química; Piranos/síntese química; Glucose/química; Glicoconjugados/química; Compostos Macrocíclicos/química; Manose/química; Conformação Molecular; Estrutura Molecular; Piranos/química; Estereoisomerismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piranos / Glicoconjugados / Compostos Macrocíclicos Idioma: En Ano de publicação: 2012 Tipo de documento: Article

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