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Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment.
Ménétrier-Caux, Christine; Faget, Julien; Biota, Cathy; Gobert, Michael; Blay, Jean-Yves; Caux, Christophe.
Afiliação
  • Ménétrier-Caux C; Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; Team 11; CRCL INSERM U-1052/CNRS 5286; Lyon, France ; LabEx DEVweCAN; Centre Léon Bérard; Lyon, France ; Centre Léon Bérard; Lyon, France.
Oncoimmunology ; 1(5): 759-761, 2012 Aug 01.
Article em En | MEDLINE | ID: mdl-22934274
Regulatory T cells (Treg) have been reported of poor prognosis for overall survival in primary breast tumors (BT). As CCL22 plays a major role in Treg recruitment within primary BT we deciphered the mechanisms involved in the CCL22 production by breast epithelial tumor cells and propose herein the major role of their innate immune recognition in this production.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article