One-pot synthesis of chitosan-g-(PEO-PLLA-PEO) via "click" chemistry and "SET-NRC" reaction.
Carbohydr Polym
; 90(4): 1515-21, 2012 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-22944410
ABSTRACT
For the development of biocompatible and degradable biomaterials, a kind of well-defined graft copolymer consisting of chitosan back-bone and amphiphilic PEO-PLLA-PEO branch chains was synthesized by Cu(0) catalyzed one-pot strategy combining "click" chemistry and single electron transfer-nitroxide radical coupling (SET-NRC) reaction. First, the precursors of 6-azide-N-phthaloyl-chitosan, TEMPO-PEO-alkyne and mPEO-PLLA-Br were designed and produced. Then, the one-pot coupling reactions between these precursors were performed in the presence of nanosized Cu and PMDETA. The efficiencies of the coupling reactions were greater than 90% determined by the FTIR and ESR spectra. The structure of graft copolymer with 43% of the grafting ratio was confirmed by the spectral analysis. This work provided a route to prepare chitosan graft copolymer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
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Materiais Biocompatíveis
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Ácido Láctico
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Quitosana
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Química Click
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Morfinanos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article