Early recurrence after curative resection in oligonodular hepatocellular carcinoma.
Hepatogastroenterology
; 60(121): 28-31, 2013.
Article
em En
| MEDLINE
| ID: mdl-22945337
ABSTRACT
BACKGROUND/AIMS:
Often patients experience an unexpected early recurrence after hepatectomy for multinodular HCC. We conducted this retrospective study to observe the recurrence rate within 1 year after hepatectomy for oligonodular HCC (2 or 3 nodules) and investigate the risk factors for early recurrence.METHODOLOGY:
The study population consisted of 102 patients with 2 or 3 HCCs that received curative resection between January 2009 and December 2009. Clinicopathological data were collected and subjected to univariate and multivariate analysis.RESULTS:
Forty-three (42.2%) patients were diagnosed as with recurrence within 1 year after hepatectomy. According to univariate analysis, the risk factors for early recurrence were alpha-fetoprotein (AFP) >200 ng/mL, microvascular involvement and lack of complete tumor capsule; microvascular involvement was an independent predictive factor for early recurrence by multivariate analysis (HR, 4.02; 95% CI, 1.42-11.39, p=0.009).CONCLUSIONS:
There was a high rate of early recurrence for patients with oligonodular HCC (2 or 3 nodules) after hepatectomy. Microvascular involvement was an independent predictive factor for early recurrence, and adjuvant therapy, such as TACE, may be considered for those patients af
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
Hepatectomia
/
Neoplasias Hepáticas
/
Recidiva Local de Neoplasia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article