An efficient synthesis of bridged heterocycles from an Ir(I) bis-amination/ring-closing metathesis sequence.
Org Lett
; 14(18): 4802-5, 2012 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-22953715
ABSTRACT
The amination of bis-allylic imidates using an Iridium(I) catalyst leads to the efficient formation of 2,6-divinyl heterocycles. Careful screening of amines, solvents, and conditions has led to the discovery of a system that favors formation of the desired cis products with synthetically useful levels of diastereoselectivity, and these results are further explained by computer based transition state energy calculations. Exposure of the heterocycles to ring-closing metathesis catalysts leads to the desired bridged heterocyclic systems.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Compostos Heterocíclicos de Anel em Ponte
/
Aminas
/
Irídio
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article