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Anti-ATP synthase autoantibodies induce neuronal death by apoptosis and impair cognitive performance in C57BL/6J mice.
Berry, Alessandra; Vacirca, Davide; Capoccia, Sara; Bellisario, Veronica; Malorni, Walter; Ortona, Elena; Cirulli, Francesca.
Afiliação
  • Berry A; Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
J Alzheimers Dis ; 33(2): 317-21, 2013.
Article em En | MEDLINE | ID: mdl-22954670
Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Apoptose / Transtornos Cognitivos / ATPases Mitocondriais Próton-Translocadoras / Neurônios Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Apoptose / Transtornos Cognitivos / ATPases Mitocondriais Próton-Translocadoras / Neurônios Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2013 Tipo de documento: Article