Anti-ATP synthase autoantibodies induce neuronal death by apoptosis and impair cognitive performance in C57BL/6J mice.
J Alzheimers Dis
; 33(2): 317-21, 2013.
Article
em En
| MEDLINE
| ID: mdl-22954670
Previous studies have suggested a pathogenetic role of autoantibodies (Abs) against ATP synthase (ATPs) in patients with Alzheimer's disease (AD). Using a mouse model, we found that intracerebroventricular administration of anti-ATPs-Abs, purified from AD patients, leads to poor cognitive performance and pronounced cell damage in the hippocampus, a brain region specifically involved in learning and memory processes, which is severely affected in AD. Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases.
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Apoptose
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Transtornos Cognitivos
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ATPases Mitocondriais Próton-Translocadoras
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Neurônios
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article