Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis.
Allergy
; 67(11): 1347-56, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22978320
ABSTRACT
Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinusite
/
Staphylococcus aureus
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Eicosanoides
/
Superantígenos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article