Structure and biosynthesis of the antibiotic bottromycin D.
Org Lett
; 14(19): 5050-3, 2012 Oct 05.
Article
em En
| MEDLINE
| ID: mdl-22984777
ABSTRACT
Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Antibacterianos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article