PAR-1 polymorphisms and risk of Helicobacter pylori-related gastric cancer in a Chinese population.

ABSTRACT

BACKGROUND: PAR-1 has been involved in inflammation of the gastrointestinal tract, tumour cell growth and invasion of gastric carcinoma cells. Thus, we aimed at determining, for the first time, the association between PAR-1 - 506 ins/del and -IVSn-14 A/T and risk of Helicobacter pylori-related gastric cancer (GC) in an ethnic Chinese population. MATERIALS AND METHODS: A case-control study comprising of 225 ethnic Chinese individuals (77 non-cardia GC cases and 148 controls with functional dyspepsia) was conducted. PAR-1 IVSn-14 A/T and 506 ins/del were genotyped by means of real-time PCR and MALDI-TOF mass spectrometry, respectively. RESULTS: H. pylori infection, male gender and the PAR-1 IVSn-14 TT genotype increased GC risk (OR3.15, 95% CI1.54-6.45, OR2.44, 95% CI1.35-4.42 and OR2.58, 95% CI1.09-6.13, respectively). PAR-1 -506 ins/del did not provide significant results. CONCLUSION: PAR-1 IVSn-14 T allele is a risk factor for H. pylori-related GC in ethnic Chinese subjects. PAR-1 -506 ins/del polymorphism is not involved in gastric carcinogenesis.