[A case of paclitaxel-induced peripheral neuropathy successfully treated with pregabalin].
Gan To Kagaku Ryoho
; 39(9): 1443-5, 2012 Sep.
Article
em Ja
| MEDLINE
| ID: mdl-22996788
ABSTRACT
Were port a 51-year-old male left renal pelvic cancer patient with paclitaxel (PTX)-induced peripheral neuropathy, which was successfully treated with pregabalin. From June 2010, a gemcitabine/PTX (GP) regimen was used as third-line treatment. In order to relieve the PTX-induced peripheral neuropathy, pregabalin (75mg/day, at night) was administered from day 6 of the 16th course. Moreover, pregabalin was increased to 150mg/day from day 12 of the course. Sensory neurotoxicity after the administration of pregabalin was decreased from CTCAE (version 4. 0) grade 3 to 1 at day 19 of the course. Therefore, there is a possibility that the PTX -induced peripheral neuropathy may be improved by pregabalin administration. Further trials may be needed to confirm the value of pregabalin.
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Base de dados:
MEDLINE
Assunto principal:
Paclitaxel
/
Doenças do Sistema Nervoso Periférico
/
Ácido gama-Aminobutírico
Limite:
Humans
/
Male
/
Middle aged
Idioma:
Ja
Ano de publicação:
2012
Tipo de documento:
Article