Plasticity of inhibition.
Neuron
; 75(6): 951-62, 2012 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-22998865
ABSTRACT
Until recently, the study of plasticity of neural circuits focused almost exclusively on potentiation and depression at excitatory synapses on principal cells. Other elements in the neural circuitry, such as inhibitory synapses on principal cells and the synapses recruiting interneurons, were assumed to be relatively inflexible, as befits a role of inhibition in maintaining stable levels and accurate timing of neuronal activity. It is now evident that inhibition is highly plastic, with multiple underlying cellular mechanisms. This Review considers these recent developments, focusing mainly on functional and structural changes in GABAergic inhibition of principal cells and long-term plasticity of glutamateric recruitment of inhibitory interneurons in the mammalian forebrain. A major challenge is to identify the adaptive roles of these different forms of plasticity, taking into account the roles of inhibition in the regulation of excitability, generation of population oscillations, and precise timing of neuronal firing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neurônios GABAérgicos
/
Rede Nervosa
/
Inibição Neural
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article