Universal protein fluctuations in populations of microorganisms.
Phys Rev Lett
; 108(23): 238105, 2012 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-23003996
ABSTRACT
The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics. We show here that protein distributions measured under a broad range of biological realizations collapse to a single non-gaussian curve under scaling by the first two moments. Moreover, in all experiments the variance is found to depend quadratically on the mean, showing that a single degree of freedom determines the entire distribution. Our results imply that protein fluctuations do not reflect any specific molecular or cellular mechanism, and suggest that some buffering process masks these details and induces universality.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Proteínas de Escherichia coli
/
Proteínas de Saccharomyces cerevisiae
/
Escherichia coli
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article