NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma.
Immunol Cell Biol
; 90(10): 983-6, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-23010873
ABSTRACT
Asbestos exposure can result in serious and frequently lethal diseases, including malignant mesothelioma. The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this complex is essential for asbestos-induced cancers. Here, we report that acute interleukin-1ß production and recruitment of immune cells into peritoneal cavity were significantly decreased in the NLRP3-deficient mice after the administration of asbestos. However, NLRP3-deficient mice displayed a similar incidence of malignant mesothelioma and survival times as wild-type mice. Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma. Notably, in a two-stage carcinogenesis-induced papilloma model, NLRP3-deficient mice showed a resistance phenotype in two different strain backgrounds, suggesting a tumour-promoting role of NLRP3 in certain chemically-induced cancer types.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Papiloma
/
Neoplasias Pleurais
/
Neoplasias Cutâneas
/
Proteínas de Transporte
/
Mesotelioma
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article