Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.
Org Biomol Chem
; 11(2): 257-60, 2013 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-23033172
ABSTRACT
The first total synthesis of (29S,37S)-malevamide E (1), a potent ion channel inhibitor, has been achieved in a convergent fashion involving Julia-Kocienski olefination, Urpi acetal aldol and Shiina macrolactonization reactions as the key steps. The strategy developed herein is amenable for the synthesis of the other possible isomers in search for the correct stereoisomer of the naturally occurring molecule.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Química Orgânica
/
Depsipeptídeos
/
Moduladores de Transporte de Membrana
/
Canais Iônicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article