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N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists.
Nirogi, Ramakrishna V S; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P K.
Afiliação
  • Nirogi RV; Discovery Research, Suven Life Sciences Ltd, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India. ramakrishna_nirogi@yahoo.co.in
Bioorg Med Chem Lett ; 22(22): 6980-5, 2012 Nov 15.
Article em En | MEDLINE | ID: mdl-23036955
ABSTRACT
The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT(6) receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas da Serotonina / Sulfonamidas / Carbazóis / Receptores de Serotonina / Aminas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antagonistas da Serotonina / Sulfonamidas / Carbazóis / Receptores de Serotonina / Aminas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article