The regenerative peptide thymosin ß4 accelerates the rate of dermal healing in preclinical animal models and in patients.
Ann N Y Acad Sci
; 1270: 37-44, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23050815
ABSTRACT
Chronic nonhealing cutaneous wounds are a worldwide problem with no agent able to promote healing. A naturally occurring, endogenous repair molecule, thymosin beta 4 (Tß4), has many biological activities that promote dermal repair. It is released by platelets at the site of injury and initiates the repair cascade. Tß4 accelerated dermal healing of full-thickness punch wounds in various animal models, including normal rats and mice, steroid-treated rats, diabetic mice, and aged mice. Furthermore, in two phase 2 clinical trials of stasis and pressure ulcers, it was found to accelerate healing by almost a month in those patients that did heal. Tß4 likely acts to repair and regenerate wounds by promoting cell migration and stem cell mobilization and differentiation, and by inhibiting inflammation, apoptosis, and infection. We conclude that Tß4 is a multifunctional regenerative peptide important in dermal repair.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
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Timosina
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Cicatrização
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article