Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.
Bioorg Med Chem
; 20(22): 6648-54, 2012 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-23062711
ABSTRACT
A series of dihydro-pyrazolyl-thiazolinone derivatives (5a-5t) have been synthesized and their biological activities were also evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. Among these compounds, compound 2-(3-(3,4-dimethylphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one (5a) displayed the most potent COX-2 inhibitory activity with IC(50) of 0.5µM, but weak to COX-1. Docking simulation was performed to position compound 5a into the COX-2 active site to determine the probable binding model. Based on the preliminary results, compound 5a with potent inhibitory activity and low toxicity would be a potential and selective anti-cyclooxygenase-2 agent.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Tiazóis
/
Ciclo-Oxigenase 2
/
Inibidores de Ciclo-Oxigenase 2
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article