Label-free imaging of cerebral ß-amyloidosis with extended-focus optical coherence microscopy.
J Neurosci
; 32(42): 14548-56, 2012 Oct 17.
Article
em En
| MEDLINE
| ID: mdl-23077040
ABSTRACT
We demonstrate label-free imaging of cerebral ß-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended-focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual ß-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the alzheimeric sample under investigation. xfOCM also opens the possibility to perform minimally invasive studies of ß-amyloid pathology in vivo, without the use of labeling methods, which potentially confound experimental findings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
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Angiopatia Amiloide Cerebral
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Tomografia de Coerência Óptica
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Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article