Aggregate formation and radiolytic degradation of amphiphilic DNA block copolymer possessing disulfide bond.
Bioorg Med Chem Lett
; 22(23): 7045-7, 2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-23084897
ABSTRACT
We have designed a novel aggregate of DNA block copolymer (DBC) that is sensitive to hypoxic X-irradiation. The DBC consists of tetrahydropyrane-protected 2-hydroxyethyl methacrylate as a hydrophobic unit and oligodeoxynucleotides as a hydrophilic unit, which are linked to a radiation-sensitive disulfide bond. The DBC self-assembled efficiently to form aggregates that encapsulated small molecules such as nile red and pyrene. Hypoxic X-irradiation could then induce reductive degradation of the DBC aggregates via an exchange reaction of the disulfide bond to release guest molecules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
DNA
/
Dissulfetos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article