Duration of membrane rupture and risk of perinatal transmission of HIV-1 in the era of combination antiretroviral therapy.
Am J Obstet Gynecol
; 207(6): 482.e1-5, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23103331
ABSTRACT
OBJECTIVE:
The objective of the study was to determine whether the duration of membrane rupture of 4 or more hours is a significant risk factor for perinatal transmission of human immunodeficiency virus (HIV) in the era of combination antiretroviral therapy (ART). STUDYDESIGN:
This was a prospective cohort study of 717 HIV-infected pregnant women-infant pairs with a delivery viral load available who received prenatal care and delivered at our institution during the interval 1996-2008.RESULTS:
The cohort comprised 707 women receiving ART who delivered during this interval. The perinatal transmission rate was 1% in women with membranes ruptured for less than 4 hours and 1.9% when ruptured for 4 or more hours. For 493 women with a delivery viral load less than 1000 copies/mL receiving combination ART in pregnancy, there were no cases of perinatal transmission identified up to 25 hours of membrane rupture. Logistic regression demonstrated only a viral load above 10,000 copies/mL as an independent risk factor for perinatal transmission.CONCLUSION:
Duration of membrane rupture of 4 or more hours is not a risk factor for perinatal transmission of HIV in women with a viral load less than 1000 copies/mL receiving combination ART.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
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Ruptura Prematura de Membranas Fetais
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Infecções por HIV
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HIV-1
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Transmissão Vertical de Doenças Infecciosas
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Fármacos Anti-HIV
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article