Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology.
Int J Mol Sci
; 13(9): 10828-10862, 2012.
Article
em En
| MEDLINE
| ID: mdl-23109824
ABSTRACT
Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
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Técnicas de Transferência de Genes
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Vetores Genéticos
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Neoplasias Pulmonares
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article