Chronic hepatitis B and C co-infection increased all-cause mortality in HAART-naive HIV patients in Northern Thailand.
Epidemiol Infect
; 141(9): 1840-8, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23114262
ABSTRACT
A total of 755 highly active antiretroviral therapy (HAART)-naive HIV-infected patients were enrolled at a government hospital in Thailand from 1 June 2000 to 15 October 2002. Census dateo f survival was on 31 October 2004 or the date of HAART initiation. Of 700 (92.6%) patients with complete data, the prevalence of hepatitis B virus (HBV) surface antigen and anti-hepatitis C virus (HCV) antibody positivity was 11.9% and 3.3%, respectively. Eight (9.6%) HBV co-infected patients did not have anti-HBV core antibody (anti-HBcAb). During 1166.7 person-years of observation (pyo), 258 (36.9%) patients died [22.1/100 pyo, 95% confidence interval (CI) 16.727.8]. HBV and probably HCV co-infection was associated with a higher mortality with adjusted hazard ratios (aHRs) of 1.81 (95% CI 1.302.53) and 1.90 (95% CI0.983.69), respectively. Interestingly, HBV co-infection without anti-HBc Ab was strongly associated with death (aHR 6.34, 95% CI 3.9910.3). The influence of hepatitis co-infection on the natural history of HAART-naive HIV patients requires greater attention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
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Hepatite B Crônica
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Hepatite C Crônica
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Coinfecção
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article