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RGG repeats of PrP-like Shadoo protein bind nucleic acids.
Lau, Agnes; Mays, Charles E; Genovesi, Sacha; Westaway, David.
Afiliação
  • Lau A; Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta T6G 2M8, Canada.
Biochemistry ; 51(45): 9029-31, 2012 Nov 13.
Article em En | MEDLINE | ID: mdl-23121093
Shadoo (Sho) is a central nervous system glycoprotein with characteristics similar to those of the cellular prion protein PrP(C), each containing a highly conserved hydrophobic domain (HD) and an N-terminal repeat region. Whereas PrP(C) includes histidine-containing octarepeats, the Sho region N-terminal to the HD includes tandem positively charged "RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA in vitro via this arginine-rich region.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Bacteriano / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Bacteriano / Proteínas do Tecido Nervoso Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2012 Tipo de documento: Article