Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells.
Immunity
; 37(5): 917-29, 2012 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-23142782
ABSTRACT
The bone marrow (BM) has been identified as a possible organ for T cell priming, yet the fundamental mechanisms of a polyclonal immune response in the BM remain unknown. We found that after intradermal injection of modified vaccinia Ankara virus, unexpected sources of newly primed polyclonal virus-specific CD8(+), but not CD4(+), T cells were localized in the BM and the draining lymph nodes (dLNs) prior to blood circulation. We identified neutrophils as the virus-carrier cells from the dermis to the BM. In both neutrophil-depleted and Ccr1(-/-) mice, virus-specific BM CD8(+) responses were lost. Myeloid antigen-presenting cells were required for BM CD8(+) T cell priming. A systems biology analysis of dLN and BM virus-specific CD8(+) T cells revealed distinct transcriptional and multifunctional profiles for cells primed in each organ. We provide direct evidence for how antigen is transported to the BM, providing a source of virus-specific memory CD8(+) T cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
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Linfócitos T CD8-Positivos
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Derme
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Memória Imunológica
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Antígenos
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Neutrófilos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article