Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens.
Nat Neurosci
; 15(12): 1624-6, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23143514
ABSTRACT
We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potenciais de Ação
/
Transdução de Sinais
/
Núcleo Accumbens
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article