Evolution of genetic and genomic features unique to the human lineage.
Nat Rev Genet
; 13(12): 853-66, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23154808
ABSTRACT
Given the unprecedented tools that are now available for rapidly comparing genomes, the identification and study of genetic and genomic changes that are unique to our species have accelerated, and we are entering a golden age of human evolutionary genomics. Here we provide an overview of these efforts, highlighting important recent discoveries, examples of the different types of human-specific genomic and genetic changes identified, and salient trends, such as the localization of evolutionary adaptive changes to complex loci that are highly enriched for disease associations. Finally, we discuss the remaining challenges, such as the incomplete nature of current genome sequence assemblies and difficulties in linking human-specific genomic changes to human-specific phenotypic traits.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Evolução Molecular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article