Novel 3' ends that support translation.

ABSTRACT

The 3' ends of two large noncoding RNAs, MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) and MEN ß, are formed by cleavage by RNase P and are capped but not polyadenylated. In the November 1, 2012, issue of Genes & Development, Wilusz and colleagues (pp. 2392-2407) show that when these 3' ends are formed on a GFP reporter, the resulting mRNA is exported to the cytoplasm and translated. The 3' end forms a novel triple-helical structure that supports export and translation as well as a poly(A) tail does.