The ß-catenin destruction complex.
Cold Spring Harb Perspect Biol
; 5(1): a007898, 2013 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-23169527
ABSTRACT
The Wnt/ß-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator ß-catenin is degraded by a multiprotein "destruction complex" that includes the tumor suppressors Axin and adenomatous polyposis coli (APC), the Ser/Thr kinases GSK-3 and CK1, protein phosphatase 2A (PP2A), and the E3-ubiquitin ligase ß-TrCP. The complex generates a ß-TrCP recognition site by phosphorylation of a conserved Ser/Thr-rich sequence near the ß-catenin amino terminus, a process that requires scaffolding of the kinases and ß-catenin by Axin. Ubiquitinated ß-catenin is degraded by the proteasome. The molecular mechanisms that underlie several aspects of destruction complex function are poorly understood, particularly the role of APC. Here we review the molecular mechanisms of destruction complex function and discuss several potential roles of APC in ß-catenin destruction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Beta Catenina
/
Complexo de Sinalização da Axina
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article