Decline in health status of extremely premature neonates with patent ductus arteriosus after second course of medical therapy.
Eur J Pediatr Surg
; 23(4): 270-2, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23172563
ABSTRACT
INTRODUCTION:
Many neonatal centers offer surgical ligation of patent ductus arteriosus (PDA) after two failed courses of pharmacologic therapy. This study compares health status of extremely premature (< 28 weeks gestation) neonates who failed medical therapy at the time of their second course of medical treatment versus operation. MATERIALS ANDMETHODS:
A retrospective chart review was performed on neonates born at less than 28 weeks gestation who underwent PDA ligation after two rounds of medical therapy over a 7.5-year period. Measurements of health status at the time of the second course of medical therapy and the time of operation were compared.RESULTS:
Neonates (n = 34) required less fraction of inspired oxygen (33.5 ± 12.9% vs. 48.5 ± 24%, p < 0.0001), had lower mean airway pressure (7.5 ± 1.9 vs. 9.1 ± 2.4 mm Hg, p < 0.0001), and were less likely to require vasopressor support (16.7 vs. 60%, p = 0.0126) at the time of the start of second course than at surgery.CONCLUSION:
Our study suggests that extremely premature neonates show a decline in cardiopulmonary reserve between a second course of medical therapy and surgical intervention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
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Indometacina
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Nível de Saúde
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Permeabilidade do Canal Arterial
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Lactente Extremamente Prematuro
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Doenças do Prematuro
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article