Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures.
J Exp Clin Cancer Res
; 31: 98, 2012 Nov 26.
Article
em En
| MEDLINE
| ID: mdl-23181722
ABSTRACT
Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early intestinal-type gastric cancer. However, its prognostic value and significance in gastric cancer remain controversial. A meta-analysis based on published studies was performed to obtain an accurate evaluation of the association between the presence of Cdx2-positive in clinical samples and clinical outcome. A total of 13 eligible retrospective cohort studies with 1513 patients were included. Cdx2-positive cases were significantly associated with higher male-to-female ratio (RR=1.27, 95% CI 1.17-1.38, P<0.00001 fixed-effect), lower (I+II) clinical stage (RR=1.63, 95% CI 1.42-1.87, P<0.00001 fixed-effect), better histologic differentiation (RR=1.54, 95% CI 1.34-1.76, P<0.00001 fixed-effect), and lower rate of vascular invasion (RR=1.23, 95% CI 1.08-1.41, P=0.002 fixed-effect) and lymph node metastasis (RR=1.52, 95% CI 1.33-1.73, P<0.00001 fixed-effect), as well as higher 5-year survival rate (HR=2.22, 95% CI 1.78-2.75, P<0.00001 fixed-effect). However, the presence of Cdx2 was not associated with tumor size. In summary, Cdx2 is a prognostic factor in gastric cancer, which acts as a marker of good outcome in patients with gastric cancer. Further clinical studies are needed to confirm the role of Cdx2 in clinical practice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prognóstico
/
Neoplasias Gástricas
/
Biomarcadores Tumorais
/
Proteínas de Homeodomínio
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article