Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins.
Biol Cell
; 105(3): 109-17, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23189935
ABSTRACT
Dewetting is the spontaneous withdrawal of a liquid film from a non-wettable surface by nucleation and growth of dry patches. Two recent reports now propose that the principles of dewetting explain the physical phenomena underpinning the opening of transendothelial cell macroaperture (TEM) tunnels, referred to as cellular dewetting. This was discovered by studying a group of bacterial toxins endowed with the property of corrupting actomyosin cytoskeleton contractility. For both liquid and cellular dewetting, the growth of holes is governed by a competition between surface forces and line tension. We also discuss how the dynamics of TEM opening and closure represent remarkable systems to investigate actin cytoskeleton regulation by sensors of plasma membrane curvature and investigate the impact on membrane tension and the role of TEM in vascular dysfunctions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Actomiosina
/
Proteínas
/
Molhabilidade
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Células Endoteliais
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article