Soluble aß promotes wild-type tau pathology in vivo.
J Neurosci
; 32(48): 17345-50, 2012 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-23197725
ABSTRACT
Growing evidence suggests that soluble Aß species can drive Alzheimer disease (AD) pathogenesis by inducing a cascade of events including tau hyperphosphorylation, proteasome impairment, and synaptic dysfunction. However, these studies have relied largely on in vitro approaches to examine the role of soluble Aß in AD. In particular, it remains unknown whether soluble Aß oligomers can facilitate the development of human wild-type tau pathology in vivo. To address this question, we developed a novel transgenic model that expresses low levels of APP with the Arctic familial AD mutation to enhance soluble Aß oligomer formation in conjunction with wild-type human tau. Using a genetic approach, we show that reduction of ß-site APP cleaving enzyme (BACE) in these ArcTau mice decreases soluble Aß oligomers, rescues cognition, and, more importantly, reduces tau accumulation and phosphorylation. Notably, BACE reduction decreases the postsynaptic mislocalization of tau in ArcTau mice and reduces the association between NMDA receptors and PSD-95. These studies provide critical in vivo evidence for a strong mechanistic link between soluble Aß, wild-type tau, and synaptic pathology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Peptídeos beta-Amiloides
/
Proteínas tau
/
Doença de Alzheimer
/
Aprendizagem
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article