Is urinary kidney injury molecule-1 a noninvasive marker for renal scarring in children with vesicoureteral reflux?
Urology
; 81(1): 168-72, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-23200959
ABSTRACT
OBJECTIVE:
To examine whether (1) levels of urinary kidney injury molecule-1 (KIM-1), a transmembrane protein and biomarker for renal tubular damage, increase in children with of vesicoureteral reflux (VUR), and (2) if KIM-1 predicts the grade of renal scarring in children with VUR.METHODS:
The study included 59 VUR patients with renal scarring, 5 VUR patients without renal scarring and 25 healthy controls aged 1 to 17 years. Dimercaptosuccinic acid scans were performed for determination of scarring and graded by 3 independent, blinded pediatric urologists for renal scarring according to the Randomized Intervention for Children with VUR study criteria. Spot urine samples were obtained. Urinary KIM-1 and creatinine levels were measured and the KIM-1/creatinine ratio was calculated.RESULTS:
Urine geometric mean KIM-1 levels (ng/mg creatinine) were significantly higher in VUR patients than in healthy controls (P=.018). Although the correlation between VUR grade and geometric mean KIM-1 levels was not significant, a positive correlation was found for scarring grade and geometric mean KIM-1 levels (r=.30, P=.02). When the patients were divided by subgroups according to scarring grade (group I, grade 1; group II, grades 2 and 3; group III, grade 4), the log KIM-1 in group III was significantly higher than in group I (P=.004).CONCLUSION:
Urinary KIM-1 levels might be used as a noninvasive marker, particularly in showing severe scarring in children with VUR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Refluxo Vesicoureteral
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Glicoproteínas de Membrana
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Cicatriz
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article