The A-nucleotide preference of HIV-1 in the context of its structured RNA genome.
RNA Biol
; 10(2): 211-5, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23235488
ABSTRACT
A bipartition of HIV-1 RNA genome sequences into single- and double-stranded nucleotides is possible based on the secondary structure model of a complete 9 kb genome. Subsequent analysis revealed that the well-known lentiviral property of A-accumulation is profoundly present in single-stranded domains, yet absent in double-stranded domains. Mutational rate analysis by means of an unrestricted model of nucleotide substitution suggests the presence of an evolutionary equilibrium to preserve this biased nucleotide distribution.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Nucleotídeos de Adenina
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HIV-1
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Genoma Viral
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article