Prevalence of the human papillomavirus (HPV) expression of the inner prepuce in asymptomatic boys and men.
World J Urol
; 31(6): 1389-94, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23239104
ABSTRACT
OBJECTIVE:
To investigate the prevalence of high-risk (HR) and low-risk (LR) human papillomavirus (HPV) in prepuces of boys and men without any HPV related lesions. PATIENTS ANDMETHODS:
Between 2009 and 2011, a total collective of 250 boys and men were investigated in this prospective study. The samples were subdivided into 3 groups regarding their age, consisting of 125 (50%) children (0-10 years), 38 (15.2%) adolescents (11-20 years) and 87 (34.8%) adults (>20 years). In situ hybridization (ISH) was performed to detect HR and LR virus types within the epithelium, followed by microscopic interpretation and determination between episomal and integrative signal pattern.RESULTS:
Our results revealed high levels of HPV concentration (HR and LR) in all age groups HR versus LR positivity was seen in 45.5 versus 35% (children), 60.6 versus 63.6% (adolescents) and 58.3 versus 48.6% (adults). The topmost rate of HR (59.8%)- and LR (50.6%)-positive probes was found in the group with high estimated sexual activity (>14 years).CONCLUSION:
Concerning the high prevalence of male HPV infection even in children, indicating non-sexual transmission pathways, inclusion of boys in the vaccination program seems to be required reducing their burden of HPV related disease.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
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Infecções por Papillomavirus
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Prepúcio do Pênis
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Infecções Assintomáticas
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article