Expanding roles for GILT in immunity.
Curr Opin Immunol
; 25(1): 103-8, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23246037
ABSTRACT
Gamma-interferon-inducible lysosomal thiol reductase (GILT), a thioredoxin-related oxidoreductase, functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. However, recent reports have greatly expanded our understanding of GILT's function. Several studies of GILT and antigen processing have shown that the influence of GILT on the peptide repertoire can alter the character of the immune response and affect central tolerance. Furthermore, a few unexpected roles for GILT have been uncovered as a host factor for Listeria monocytogenes infection, in the maintenance of cellular glutathione (GSH) levels, and possibly outside the cell, as enzymatically active GILT is secreted by activated macrophages.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
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Oxirredutases atuantes sobre Doadores de Grupo Enxofre
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Listeriose
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Listeria monocytogenes
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Macrófagos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article