Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure.
Cell Immunol
; 279(2): 180-6, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23246680
ABSTRACT
American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⺠T cells, capable of inducing opposite disease profiles, and CD8⺠T cells, that are related to immuno protection. We characterized T lymphocytes from patients before and after treatment, patients that spontaneously healed and controls, also evaluating their production of IL-10, IL-4, TNF-α and IFN-γ, after stimulation with soluble/insoluble antigenic fractions of Leishmania (Viannia) braziliensis. We observed the production of suppressive cytokines in the early phase of leishmaniasis with significant presence CD4⺠T cells, suggesting their connection with disease progression. After healing, the immune pattern observed was a type 1 response, what seems to be associated with cure and/or protection in the ACL. The results also showed that both fractions induced a specific immune response, contributing to the search for relevant antigens in this disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leishmania braziliensis
/
Linfócitos T CD4-Positivos
/
Leishmaniose Cutânea
/
Linfócitos T CD8-Positivos
Limite:
Humans
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article