Copper-boosting compounds: a novel concept for antimycobacterial drug discovery.
Antimicrob Agents Chemother
; 57(2): 1089-91, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23254420
ABSTRACT
We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against replicating and nonreplicating M. tuberculosis strains.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Ensaios de Triagem em Larga Escala
/
Mycobacterium tuberculosis
/
Antituberculosos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article