Simvastatin protects hepatocytes from apoptosis by suppressing the TNF-&#945;/caspase-3 signaling pathway in mice with burn injury.

Zhao, Gaofeng; Yu, Yong-Ming; Kaneki, Masao; Tompkins, Ronald G; Fischman, Alan J

Simvastatin protects hepatocytes from apoptosis by suppressing the TNF-α/caspase-3 signaling pathway in mice with burn injury.

Zhao, Gaofeng; Yu, Yong-Ming; Kaneki, Masao; Tompkins, Ronald G; Fischman, Alan J.

Afiliação

Zhao G; Surgical Service, Massachusetts General Hospital, Shriners Hospitals for Children, and Harvard Medical School, Boston, MA 02114, USA. jingxizh@yahoo.com

Ann Surg ; 257(6): 1129-36, 2013 Jun.

Article em En | MEDLINE | ID: mdl-23275311

Assuntos

Apoptose/efeitos dos fármacos; Queimaduras/metabolismo; Caspase 3/metabolismo; Hepatócitos/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Sinvastatina/farmacologia; Fator de Necrose Tumoral alfa/metabolismo; Animais; Western Blotting; Camundongos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Queimaduras / Transdução de Sinais / Fator de Necrose Tumoral alfa / Apoptose / Sinvastatina / Hepatócitos / Caspase 3 Limite: Animals Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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