Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
Eur J Med Chem
; 60: 120-7, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23287057
ABSTRACT
Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
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Tionas
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Neoplasias da Mama
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Cumarínicos
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Descoberta de Drogas
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Antineoplásicos
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article