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The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease.
Deuring, J Jasper; de Haar, Colin; Kuipers, Ernst J; Peppelenbosch, Maikel P; van der Woude, C Janneke.
Afiliação
  • Deuring JJ; Erasmus MC - University Medical Centre Rotterdam, Department Gastroenterology and Hepatology, The Netherlands.
Int J Biochem Cell Biol ; 45(4): 798-806, 2013 Apr.
Article em En | MEDLINE | ID: mdl-23291352
ABSTRACT
The epithelial layer of our intestines must meet two opposing requirements. On one hand it must allow for efficient uptake of nutrients and fluids, on the other hand it is a vital defence barrier between the milieu interior and the milieu exterior. In contrast to the lung that by virtue of cilia movement is kept virtually sterile, the gut epithelium is confronted by a stupendous microbiological load and a substantial xenobiotic challenge. The efficiency by which our intestinal epithelium manages to deal with the challenge of efficient nutrient absorption while simultaneously fulfilling its barrier function is testimony to what the forces of evolution can accomplish. Importantly, our understanding as to how our gut epithelial compartment manages this balancing act is now rapidly emerging, answering one of the oldest questions in cell biology. Importantly, when aberrations in this balance occur, for instance as a consequence genetic polymorphisms, increased propensity to develop chronic inflammation and inflammatory bowel disease is the result. Thus the knowledge on intestinal cell biology and biochemistry is not only of academic interest but may also aid design of novel avenues for the rational treatment of mucosal disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Biologia Celular / Mucosa Intestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Biologia Celular / Mucosa Intestinal Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article