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Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Parmentier-Batteur, Sophie; Hutson, Peter H; Menzel, Karsten; Uslaner, Jason M; Mattson, Britta A; O'Brien, Julie A; Magliaro, Brian C; Forest, Thomas; Stump, Craig A; Tynebor, Robert M; Anthony, Neville J; Tucker, Thomas J; Zhang, Xu-Fang; Gomez, Robert; Huszar, Sarah L; Lambeng, Nathalie; Fauré, H; Le Poul, Emannuel; Poli, Sonia; Rosahl, Thomas W; Rocher, Jean-Philippe; Hargreaves, Richard; Williams, Theresa M.
Afiliação
  • Parmentier-Batteur S; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA. Electronic address: sophie_parmentier_batteur@merck.com.
  • Hutson PH; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Menzel K; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Uslaner JM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Mattson BA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • O'Brien JA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Magliaro BC; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Forest T; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Stump CA; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Tynebor RM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Anthony NJ; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Tucker TJ; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Zhang XF; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Gomez R; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Huszar SL; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Lambeng N; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Fauré H; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Le Poul E; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Poli S; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Rosahl TW; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Rocher JP; Addex Therapeutics, 12, chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
  • Hargreaves R; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
  • Williams TM; Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486-0004, USA.
Neuropharmacology ; 82: 161-73, 2014 Jul.
Article em En | MEDLINE | ID: mdl-23291536
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Antipsicóticos / Benzamidas / Encéfalo / Morte Celular / Fármacos Atuantes sobre Aminoácidos Excitatórios / Receptor de Glutamato Metabotrópico 5 Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Antipsicóticos / Benzamidas / Encéfalo / Morte Celular / Fármacos Atuantes sobre Aminoácidos Excitatórios / Receptor de Glutamato Metabotrópico 5 Idioma: En Ano de publicação: 2014 Tipo de documento: Article