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[Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters].
Zheng, Jiu-Jia; Yang, Xu; Zhang, Li-Ya; Fei, Qian-Jin; Pan, Cheng-Shuang; Ni, Wu-Hua; Jin, Jian-Yuan; Huang, Xue-Feng.
Afiliação
  • Zheng JJ; Reproductive Medicine Center, The First Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, China. zhengjiujia@126.com
Zhonghua Nan Ke Xue ; 18(10): 925-9, 2012 Oct.
Article em Zh | MEDLINE | ID: mdl-23297503
OBJECTIVE: To investigate the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters. METHODS: We collected 535 semen samples, assessed sperm DNA damage by sperm chromatin dispersion test, and analyzed the correlation of sperm DNA damage and sperm-nucleoprotein transition with acrosin activity and seminal parameters according to the WHO criteria. RESULTS: Statistically significant differences were observed in sperm DNA damage among sperm-nucleoprotein transition, acrosin activity, sperm concentration and the percentage of grade a + b sperm (P < 0.01). Sperm DNA damage was positively correlated with age, sperm-nucleoprotein transition, sperm concentration and the percentage of grade d sperm (P < 0.01 or P < 0.05), but negatively correlated with acrosin activity (P < 0.001). Stepwise linear regression analysis demonstrated that age, sperm concentration, the percentage of grade d sperm, sperm-nucleoprotein transition and acrosin activity were independent variables related to the DNA fragmentation index (DFI). The abnormality rates of sperm-nucleoprotein transition, acrosin activity, sperm concentration and graded a + b sperm were significantly higher in the sperm DNA damage group (DFI > or = 30%) than in the normal control (DFI < 30%) (P < 0.01). CONCLUSION: Sperm DNA damage is closely related with sperm-nucleoprotein transition, acrosin activity and seminal parameters, which may become another important independent parameter for the evaluation of sperm quality.
Assuntos
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Base de dados: MEDLINE Assunto principal: Espermatozoides / Dano ao DNA / Acrosina / Infertilidade Masculina / Nucleoproteínas Limite: Adult / Humans / Male Idioma: Zh Ano de publicação: 2012 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Espermatozoides / Dano ao DNA / Acrosina / Infertilidade Masculina / Nucleoproteínas Limite: Adult / Humans / Male Idioma: Zh Ano de publicação: 2012 Tipo de documento: Article