Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands.
J Virol
; 87(6): 3592-6, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23302869
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândulas Salivares
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Muromegalovirus
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Proteína Killer-Antagonista Homóloga a bcl-2
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article