Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.
J Nat Prod
; 76(1): 79-84, 2013 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-23305465
ABSTRACT
Eight grifolin derivatives, involving three new monomers, albatrelins A-C (1-3), three novel dimers (meroterpenoid pigments), albatrelins D-F (4-6), and two known ones, 6a,7,8,9,10,10a-hexahydro-3,6,9-trimethyl-6-(4-methyl-3-penten-1-yl)-1,9-epoxy-6H-dibenzo[b,d]pyran (7) and confluentin (8), were isolated from Albatrellus ovinus. Their structures were established by extensive spectroscopic analysis. The absolute configurations of compounds 2-4 were determined as 9R by comparing their optical rotations with data reported in the literature. Albatrelin F (6) was isolated as a pair of C-2' tautomers with a ratio of 1.31. Confluentin (8) showed weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pigmentos Biológicos
/
Basidiomycota
/
Produtos Biológicos
/
Antineoplásicos
Limite:
Female
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article