Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Bioorg Med Chem Lett
; 23(4): 1046-50, 2013 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-23312472
ABSTRACT
We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhibit good inhibition activity and excellent kinase selectivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Receptores Proteína Tirosina Quinases
/
Inibidores de Proteínas Quinases
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article