The association between home parenteral nutrition and patients with FAP-associated intra-abdominal desmoids: a retrospective study.
JPEN J Parenter Enteral Nutr
; 37(5): 683-8, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23319384
ABSTRACT
BACKGROUND:
Intra-abdominal desmoid tumors (IADTs) are a common complication of familial adenomatous polyposis (FAP). Treatment is not standardized for advanced disease. Medical and surgical treatments may be ineffective in preventing complications, which can cause intestinal failure. Home parenteral nutrition (HPN) can be a life-saving treatment in these patients. The aim of this study was to investigate the association with HPN in FAP-IADTs.METHODS:
A retrospective review of FAP patients with IADTs at the Cleveland Clinic (CC) between 1980 and 2009 was performed. Patients and tumor characteristics were retrieved from the CC Jagelman Registry for Inherited Neoplasms and CC HPN database. Inclusion criteria were FAP-IADTs and 6-month follow up at CC. Exclusion criteria were <6-month follow-up, lack of 3-dimensional lesion or sheet desmoid, and/or incomplete medical records. Kaplan-Meier curves were analyzed for HPN and non-HPN groups.RESULTS:
One hundred fifty-four patients were included and divided into 2 groups HPN (n = 41, 26.6%) and non-HPN (n = 113, 73.4%). The HPN group was more likely to have advanced-stage disease and significantly higher incidence of chronic abdominal pain, narcotic dependency, bowel obstruction, ureteral obstruction, deep vein thrombosis, pulmonary embolism, fistulae, and sepsis (P < .05). The need for HPN represented a strong predictor of mortality (5-year survival HPN = 72% vs non-HPN = 95%), but duration of HPN did not affect mortality.CONCLUSION:
HPN, although a life-saving treatment, is an independent poor prognostic factor associated with high morbidity and mortality.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Nutrição Parenteral no Domicílio
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Fibromatose Agressiva
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Polipose Adenomatosa do Colo
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article