A simple, closed-form, mathematical model for gas exchange in microchannel artificial lungs.
Biomed Microdevices
; 15(3): 397-406, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23329289
ABSTRACT
Microfabrication techniques are attractive for constructing artificial lungs due to the ability to create features similar in size to those in the natural lung. However, a simple and intuitive mathematical model capable of accurately predicting the gas exchange performance of microchannel artificial lungs does not currently exist. Such a model is critical to understanding and optimizing these devices. Here, we describe a simple, closed-form mathematical model for gas exchange in microchannel artificial lungs and qualify it through application to experimental data from several research groups. We utilize lumped parameters and several assumptions to obtain a closed-form set of equations that describe gas exchange. This work is intended to augment computational models by providing a more intuitive, albeit potentially less accurate, understanding of the operation and trade-offs inherent in microchannel artificial lung devices.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Órgãos Artificiais
/
Troca Gasosa Pulmonar
/
Microtecnologia
/
Pulmão
/
Modelos Teóricos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article